| PT-141 One of only two FDA-approved peptides in this space. Proven to raise sexual desire in premenopausal women, but the benefit is modest and the off-label hype outruns it. | Grade A FDA-approved / proven in humans | FDA-approved | green | Branded Vyleesi commonly ~$900 for four auto-injectors (retail) | PT-141 (bremelanotide) is an FDA-approved drug, Vyleesi (2019), for HSDD in premenopausal women, so its evidence is Grade A. The honest caveats: the benefit on desire is modest, and the other uses it's sold for (men, nasal sprays) are off-label and unproven. Access it via a licensed provider, not gray-market vials. | See the evidence → |
| Gonadorelin (GnRH) Synthetic GnRH, the master hormone that tells the pituitary to make LH and FSH. It was an FDA-approved human drug and is now widely used in compounded men's-health protocols to keep the testicular axis running during TRT. | Grade A FDA-approved / proven in humans | Compoundable (503A) | green | Compounded gonadorelin: roughly $30 to $90 per month depending on dose and pharmacy. | A real, formerly FDA-approved hormone with clean pharmacology and a sensible modern role: keeping the testicular axis alive during TRT via a compounding-pharmacy prescription. Grade A for its endocrine actions. The main caveats are that its headline TRT use is off-label and compounded, dosing frequency matters a lot, and it belongs under clinician supervision with periodic labs. | See the evidence → |
| Oxytocin A real FDA-approved hormone drug (as Pitocin) used in obstetrics for labor and postpartum bleeding. The social, bonding, and libido claims that make it popular are mostly extrapolated from small studies, not approved uses. | Grade A FDA-approved / proven in humans | FDA-approved | green | Pitocin is an inexpensive institutional injectable (a few dollars per vial, billed through hospital care). Gray-market/compounded nasal oxytocin runs roughly $30 to $70. | A genuine FDA-approved hormone, but the approval is for labor and postpartum bleeding, not for bonding, trust, or libido. For its real medical use it is Grade A and hospital-controlled because of uterine and water-intoxication risks. For the social/sexual reputation driving consumer interest, the intranasal evidence is weak and inconsistent, and gray-market sprays are unregulated. Respect the gap between the drug and the mythology. | See the evidence → |
| Kisspeptin (Kisspeptin-54 / Kisspeptin-10) An investigational reproductive hormone that sits one step above GnRH. Real, well-designed human trials show it can boost sexual-brain activity and arousal, but it is research-only and delivered by IV infusion, not a peptide you buy and inject at home. | Grade C Early / foreign human data only | Research-only | amber | No legitimate consumer market. Gray-market research vials, where they appear, run roughly $40 to $120. | One of the more scientifically interesting research peptides here, with legitimate JAMA-published RCTs showing it can activate sexual-brain circuits in people with low desire. But it is early-stage, investigational, IV-delivered, and unapproved. Promising signal, not a product. Treat home use of research-labeled kisspeptin as unproven and unsupervised. | See the evidence → |
| Melanotan-2 (MT-2) An unapproved "tanning" peptide with documented serious harms. Melanoma and mole changes, priapism, nausea, and rhabdomyolysis have all been reported. This is a safety page, not a recommendation. | Grade D Animal studies only, unproven in humans | Research-only | red | UNKNOWN | Melanotan-2 (MT-2) is an unapproved "tanning" peptide with documented serious harms: melanoma and mole changes, priapism, nausea, blood-pressure changes and rhabdomyolysis have all been reported. Human evidence is Grade D and the safety flag is red. It is not the same as FDA-approved afamelanotide (Scenesse). There is no safe or legal way to buy it, and we do not recommend it. | See the evidence → |